Biochemistry and transcriptome analysis reveal condensed tannins from mature-green bananas alleviate liver injury induced by high cholesterol diet in C57BL/6 mice by regulating cholesterol metabolism pathway

Free cholesterol has been considered to be a critical risk factor of nonalcoholic fatty liver disease (NAFLD). It remains unknown whether dietary intake condensed tannins (CTs) have distinguishable effects alleviate damage caused by high diet. Male C57BL/6 mice were fed diet for 6 weeks, and given CTs treatment at dosage 200 mg/(kg·bw·day) the same time. The results indicated that compared with normal diet, group resulted in significant weight loss, dysregulation lipid metabolism blood liver, oxidative stress but dramatically reversed these negative effects. HE staining frozen section observation manifested could effectively reduce deposition tissue necrosis intake. alleviated injury mainly regulating expression related genes pathway AMPK phosphorylation. Our confirmed remarkable lowering anti-liver in vivo.